KIN1148
KIN1148 Basic information
- Product Name:
- KIN1148
- Synonyms:
-
- KIN1148
- KIN1148;KIN-1148;KIN 1148
- N-(Benzo[1,2-d:3,4-d']bis(thiazole)-2-yl)-2-naphthamide
- 2-Naphthalenecarboxamide, N-benzo[1,2-d:3,4-d']bisthiazol-2-yl-
- N-Benzo[1,2-d:3,4-d']bisthiazol-2-yl-2-naphthalenecarboxamide
- KIN 1148,inhibit,KIN-1148,KIN1148,Influenza Virus,Inhibitor
- KIN1148, 10 mM in DMSO
- CAS:
- 1428729-56-9
- MF:
- C19H11N3OS2
- MW:
- 361.44
- Product Categories:
-
- API
- Mol File:
- 1428729-56-9.mol
KIN1148 Chemical Properties
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:55.25(Max Conc. mg/mL);152.86(Max Conc. mM)
- form
- Solid
- pka
- 9.80±0.43(Predicted)
- color
- Light yellow to yellow
KIN1148 Usage And Synthesis
Uses
N-Benzo[1,2-d:3,4-d'']bisthiazol-2-yl-2-naphthalenecarboxamide, can be used in the synthesis of other chemical compounds having therapeutic activity, such anti-viral compounds.
in vivo
Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protect against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induce an influenza virusspecific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes. Primeboost immunization with vaccine plus KIN1148, but not prime immunization alone, induce antibodies capable of inhibiting influenza virus hemagglutinin and neutralizing viral infectivity. Nevertheless, a single immunization with vaccine plus KIN1148 provide increased protection over vaccine alone and reduce viral load in the lungs after challenge[1].
KIN1148Supplier
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