mPEG4-Hydrazide Chemical Properties

Boiling point:

443.9±40.0 °C(Predicted)

Density 

1.098±0.06 g/cm3(Predicted)

pka

12.82±0.35(Predicted)

mPEG4-Hydrazide Usage And Synthesis

Biological Activity

m-PEG5-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

mPEG4-Hydrazide(1449390-65-1)Related Product Information

• MPEG12-Hydrazide
• MPEG5-Hydrazide
• MPEG24-Hydrazide
• 3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontanoic acid
• m-PEG4-Hydrazide
• 3,6,9,12,15,18,21,24,27,30-Decaoxahentriacontanoic acid
• MPEG8-Hydrazide
• MPEG6-Hydrazide
• MPEG16-Hydrazide
• MPEG36-Hydrazide
• 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanoic acid