BocNH-PEG6-CH2CH2N3 Chemical Properties

storage temp. 

Store at Room Tem.

solubility 

Soluble in DMSO, DCM, DMF

BocNH-PEG6-CH2CH2N3 Usage And Synthesis

Description

t-boc-N-amido-PEG6-azide is a azide containing crosslinking reagent with a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The reagent can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

Boc-NH-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

BocNH-PEG6-CH2CH2N3(1292268-15-5)Related Product Information

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• N3-PEG6-Hydrazide
• Azido-PEG6-NHS ester
• Azido-PEG6
• 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine
• Azide-PEG6-Tos
• Azido-PEG7-acid
• N3-PEG6-tBu