Sarolaner
Sarolaner Basic information
- Product Name:
- Sarolaner
- Synonyms:
-
- Sarolaner
- 1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
- PF 6450567;PF6450567
- PF6450567
- PF 6450567
- Sarolaner(PF-6450567)
- (S)-1-(5'-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone
- Ethanone, 1-[5'-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)-
- CAS:
- 1398609-39-6
- MF:
- C23H18Cl2F4N2O5S
- MW:
- 581.36
- Mol File:
- 1398609-39-6.mol
More
Less
Sarolaner Chemical Properties
- Boiling point:
- 722.7±70.0 °C(Predicted)
- Density
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- Store at 4°C, sealed storage, away from moisture
- solubility
- DMF: Slightly soluble; DMSO: Slightly soluble; Ethanol: Slightly soluble
- form
- A solid
- pka
- -0.93±0.20(Predicted)
- color
- White to off-white
- InChIKey
- FLEFKKUZMDEUIP-QFIPXVFZSA-N
- SMILES
- C(=O)(N1CC2(C3=C(C=C(C4C[C@](C5=CC(Cl)=C(F)C(Cl)=C5)(C(F)(F)F)ON=4)C=C3)CO2)C1)CS(C)(=O)=O
More
Less
Sarolaner Usage And Synthesis
Uses
Sarolaner is used in the making of formulations for the control of ticks in cats, and flea infestations in dogs. A parasiiticide.
in vivo
Sarolaner (2.5 mg/kg; p.o. once) shows 100% efficacious against R. sanguineus and D. reticulatus[1]. Sarolaner (1.25- 5 mg/kg; p.o. once) effectively against I. ricinus[1].
| Animal Model: | Dog infested with R. sanguineus and D. reticulatus[1] |
| Dosage: | 2.5 mg/kg |
| Administration: | Oral gavage; 2.5 mg/kg once |
| Result: | Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy againstD. reticulatus. |
| Animal Model: | Dog infested with I. ricinus[1] |
| Dosage: | 1.25, 2.5 and 5 mg/kg |
| Administration: | Oral gavage; 1.25, 2.5 and 5 mg/kg once |
| Result: | Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg. |
SarolanerSupplier
Afflon Pharmaceutical (Sichuan) Co., Ltd. Gold
- Tel
- 17336178085
- 1684779048@qq.com
Nanjing Paite Meisheng Technology Co., Ltd Gold
- Tel
- 15952038335 13327728092
- xu_meiqin@petmedtech.com
Madision Biomedical Co., Ltd. Gold
- Tel
- 028-87439248 19150327610
- 553691721@qq.com
CHENGHUI PHARMACEUTICAL GROUP LTD Gold
- Tel
- 531-58897070 15254140813
- market@jnchsd.com
Jinan Hongkangda Chemical Co., Ltd Gold
- Tel
- 0531-88901705 18753193522
- 810353473@qq.com