PF-06726304
PF-06726304 Basic information
- Product Name:
- PF-06726304
- Synonyms:
-
- PF-06726304
- 5,8-dichloro-2-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-7-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one,
- 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
- PF-6726304
- 1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-
- antitumor,H3K27me3,PF06726304,Karpas-422,EZH2,PF 06726304,Histone Methyltransferase,inhibit,Inhibitor,PF-06726304,Y641N
- PF-06726304, 10 mM in DMSO
- CAS:
- 1616287-82-1
- MF:
- C22H21Cl2N3O3
- MW:
- 446.33
- Mol File:
- 1616287-82-1.mol
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PF-06726304 Chemical Properties
- Boiling point:
- 686.8±55.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO : ≥ 15 mg/mL (33.61 mM)
- form
- powder
- pka
- 11.76±0.10(Predicted)
- color
- white to beige
- SMILES
- CC(O)=O.CC(ON=C1C)=C1C2=CC(Cl)=C(CCN(CC3=C(C)C=C(C)NC3=O)C4=O)C4=C2Cl
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PF-06726304 Usage And Synthesis
Biochem/physiol Actions
PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.
PF-06726304Supplier
Deyang Yuehe Bio-Pharmaceutical Co.,Ltd
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- 028-82729560 18030702676
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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- 028-81700200 18116577057
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Beijing Solarbio Science & Tecnology Co., Ltd.
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- 010-50973130 18101056239
- 3193328036@qq.com