LGD-3303 Chemical Properties

Boiling point:

492.0±45.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly)

pka

14.06±0.70(Predicted)

form 

Solid

color 

Pale Yellow to Light Yellow

InChI

InChI=1S/C16H14ClF3N2O/c1-3-11-8(2)14-12(22(11)7-16(18,19)20)5-4-10-15(14)9(17)6-13(23)21-10/h4-6H,3,7H2,1-2H3,(H,21,23)

InChIKey

OMXGOGXEWUCLFI-UHFFFAOYSA-N

SMILES

N1C2=C(C3C(C)=C(CC)N(CC(F)(F)F)C=3C=C2)C(Cl)=CC1=O

LGD-3303 Usage And Synthesis

Description

LGD-3303 is a selective androgen receptor modulator (SARM), which was originally developed as a means to help treat muscle wasting illnesses, as well as conditions like osteoporosi. It s a nonsteroidal, nonaromatizable androgen receptor ligand that binds to the androgen receptor with high affinity in a radiolabeled to competitive binding assay (Ki=0.9 nM)

Uses

LGD-3303 is used in methods reducing mammographic breast density and/or breast cancer risk comprising the administration of an effective administration of an androgenic agent and an effective amt. of an aromatase inhibitor. LGD-3303 is also used in combination with anti-TWEAK antibodies for treating muscle atrophy.

Side effects

LGD 3303 side effects could be an increase in cholesterol as well as an imbalance of your testosterone. Increase in blood pressure is another side effect.