BDZ-g,GYKI 47409,
BDZ-g,GYKI 47409, Basic information
- Product Name:
- BDZ-g,GYKI 47409,
- Synonyms:
-
- BDZ-g,GYKI 47409,
- AMPA/kainate antagonist-3
- Benzenamine, 4-[(8R)-8,9-dihydro-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl]-2-methyl-
- GYKI47409
- kainate antagonist-3
- (R)-5-(4-amino-3-methyl-phenyl)-8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]-benzodiazepine,(R)-5-(4-amino-3-
- BDZ-g
- (R)-2-Methyl-4-(8-methyl-7-(5-methyl-1,3,4-thiadiazol-2-yl)-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepin-5-yl)aniline
- CAS:
- 732278-52-3
- MF:
- C21H21N5O2S
- MW:
- 407.49
- Mol File:
- 732278-52-3.mol
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BDZ-g,GYKI 47409, Chemical Properties
- form
- Solid
- color
- White to yellow
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BDZ-g,GYKI 47409, Usage And Synthesis
Description
BDZ-g is a potent inhibitor of both the closed-channel and the open-channel conformations of all four homomeric AMPA receptor channels, as well as two GluA2R containing complex AMPA receptor channels.
Uses
BDZ-g is a potent, selective antagonist of AMPA receptor. BDZ-g has the potential for the research of various neurological disorders involving excessive activity of AMPA receptors[1].
References
[1] Wang C, et al. Mechanism and site of inhibition of AMPA receptors: pairing a thiadiazole with a 2,3-benzodiazepine scaffold. ACS Chem Neurosci. 2014;5(2):138-147. DOI:10.1021/cn400193u
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