1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine Chemical Properties

Boiling point:

490.6±40.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

pka

4.61±0.12(Predicted)

1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine Usage And Synthesis

Uses

N4Py is a pentadentate ligand, that forms a stable complex with metal ions, such as iron, platinum, and copper. N4py mimics the metal binding domains of iron-dependent antibiotics like Bleomycin(HY-17565), forms the DNA-cleaving FeII-N4Py complexes, generates reactive oxygen species (ROS), and causes oxidative damage in cells. N4py can be used in cancer research[1].

References

[1] Geersing A, et al., Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py. Inorg Chem. 2018 Jul 2;57(13):7748-7756. DOI:10.1021/acs.inorgchem.8b00714