Isophysalin A
Isophysalin A Basic information
- Product Name:
- Isophysalin A
- Synonyms:
-
- Isophysalin A
- PubChem ID: 57387832
- 1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,12,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,6a,10b-trimethyl-3-methylene-, (1S,2S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aS)-
- CAS:
- 1363398-67-7
- MF:
- C28H30O10
- MW:
- 526.54
- Mol File:
- 1363398-67-7.mol
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Isophysalin A Chemical Properties
- Boiling point:
- 846.6±65.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- pka
- 9.83±0.70(Predicted)
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Isophysalin A Usage And Synthesis
Uses
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1].
References
[1] Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77(5):441-7. DOI:10.1016/j.steroids.2011.11.016
Isophysalin ASupplier
Wuhan ChemFaces Biochemical Co., Ltd.
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Shanghai Hewu Biotechnology Co., LTD
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