Antihistamine-1 Chemical Properties

Boiling point:

596.0±60.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

7.66±0.10(Predicted)

color 

Off-white to light yellow

Antihistamine-1 Usage And Synthesis

Uses

1-[(4-Fluorophenyl)methyl]-2-[4-(4-methyl-1H-pyrazol-1-yl)-1-piperidinyl]-1H-benzimidazole, is a 2-aminobenzimidazole H1-antihistamines used for the treatment of insomnia. It is also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM.