ADDA 5 hydrochloride Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO : 65 mg/mL (160.10 mM)

form 

Solid

color 

White to off-white

ADDA 5 hydrochloride Usage And Synthesis

Uses

ADDA 5 hydrochloride has been used as a complex IV inhibitor to study its effects on leptomeningeal derivatives of human breast and lung cancer cells.

Biological Activity

ADDA 5 is a potent and selective inhibitor of cytochrome c oxidase (Complex IV) th at depletes the bioenergetics reserve capacity in intact glioma cells. ADDA 5 specifically inhibits the proliferation of chemosensitive and chemoresistant glioma cells, while sparing non-cancer cells. Additionally ADDA 5 is effective against glioma stem cells.