4-(4-METHOXYPHENOXY)ANILINE Chemical Properties

Melting point:

79 °C

Boiling point:

359.6±27.0 °C(Predicted)

Density 

1.155±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder

pka

4.93±0.10(Predicted)

color 

Charcoal

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2921420090

4-(4-METHOXYPHENOXY)ANILINE Usage And Synthesis

Synthesis

Step 2. Synthesis of 4-(4-methoxyphenoxy)aniline To a solution of 1-methoxy-4-(4-nitrophenoxy)benzene (12.0 g, 49 mmol) in ethyl acetate (EtOAc, 250 mL) was added 5% Pt/C catalyst (1.5 g). The resulting suspension was reacted by shaking under hydrogen atmosphere (50 psi) for 18 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth (Celite) pad to remove the catalyst. The filtrate was concentrated under reduced pressure to give an oily product, which gradually solidified on standing (10.6 g, 100% yield). The product was characterized by 1H-NMR (CDCl3): δ 3.54 (broad single peak, 2H), 3.78 (single peak, 3H), 6.65 (double peak, J = 8.8 Hz, 2H), 6.79-6.92 (multiple peaks, 6H); EI-MS m/z 215 (M+).

References

[1] Patent: US2008/269265, 2008, A1. Location in patent: Page/Page column 14
[2] Patent: EP1449834, 2004, A2. Location in patent: Page 22
[3] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 27
[4] Patent: US2007/244120, 2007, A1. Location in patent: Page/Page column 17
[5] Patent: US2003/207914, 2003, A1. Location in patent: Page/Page column 8

4-(4-METHOXYPHENOXY)ANILINE(31465-36-8)Related Product Information

• DIFENOXURON
• 1,4-Bis(4-aminophenoxy)benzene
• 2-(4-METHOXYPHENOXY)ANILINE
• 2-(2-METHOXYPHENOXY)ANILINE
• 4-(4-METHOXYPHENOXY)ANILINE
• TIMTEC-BB SBB011590
• 2-(4-METHOXYPHENOXY)-5-NITROBENZOIC ACID
• p-(p-nitrophenoxy)anisole
• 2-(4-METHOXYPHENOXY)-5-NITROBENZENE-1-CARBONYL CHLORIDE
• 5-CHLORO-2-(4-METHOXYPHENOXY)ANILINE
• 4-(3-METHOXYPHENOXY)ANILINE
• 2-(3-Methoxyphenoxy)aniline hydrochloride,2-(3-METHOXYPHENOXY)ANILINE
• 3-fluoro-4-(4-methoxyphenoxy)aniline
• 4-(2-METHOXYPHENOXY)ANILINE
• 3-chloro-4-(4-methoxyphenoxy)aniline
• 5-BROMO-2-(2-METHOXYPHENOXY)ANILINE
• 4-(4-METHOXYPHENOXY)ANILINE HYDROCHLORIDE
• 5-BROMO-2-(4-METHOXYPHENOXY)ANILINE