1,5-ISOQUINOLINEDIOL Chemical Properties

Melting point:

270-275 °C

Boiling point:

287.44°C (rough estimate)

Density 

1.2480 (rough estimate)

refractive index 

1.5050 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO: >36 mg/mL

form 

solid

pka

8.52±0.20(Predicted)

color 

off-white

CAS DataBase Reference

5154-02-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29337900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,5-ISOQUINOLINEDIOL Usage And Synthesis

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Chemical Properties

white to off-white solid

Uses

Reagent used in the preparation of PARP inhibitor.

Uses

1,5-Isoquinolinediol can be used as a reagent in the preparation of PARP inhibitor.

Definition

ChEBI: An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups.

General Description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

1,5-ISOQUINOLINEDIOL(5154-02-9)Related Product Information

• 1,5-ISOQUINOLINEDIOL
• 7-isoquinolinediol,1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-h
• 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-Tetrahydro-1-methyl-6,7-Isoquinolinediol
• 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methyl-6,7-isoquinolinediol
• 5-Hydroxyisoquinoline
• Isoquinoline
• Isocarbostyril
• 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE,1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE 98%
• 1-(3,4-Dihydroxybenzyl)-6,7-isoquinolinediol
• Tretoquinol
• (S)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride
• 5-METHOXY-2H-ISOQUINOLIN-1-ONE
• 6,7-Isoquinolinediol, 1-propyl- (9CI)
• d-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
• 6,7-Isoquinolinediol, 1-(1-methylethyl)- (9CI)
• 6,7-Isoquinolinediol, 1-[(1S)-1,2-dihydroxyethyl]-1,2,3,4-tetrahydro- (9CI)
• 3,4-Dihydro-6,7-isoquinolinediol.
• Tretoquinol hydrochloride