Tetrahydro-2H-thiopyran-4-amine Chemical Properties

Melting point:

0°C

Boiling point:

0°C

Density 

1.032±0.06 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

Storage temp. 2-8°C

form 

semi-solid

pka

9.59±0.20(Predicted)

color 

Yellow

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

20/21-36/37/39-26-22

Hazard Note 

Irritant

HS Code 

2934999090

Tetrahydro-2H-thiopyran-4-amine Usage And Synthesis

Synthesis

Step b: Lithium aluminum hydride (6.96 g, 0.183 mol) was slowly added to a solution containing tetrahydrofuran (80 mL) at 0°C, followed by dropwise addition of tetrahydro-4H-thiopyran-4-one oxime (8 g, 0.0610 mol) to a tetrahydrofuran solution (20 mL). The reaction mixture was refluxed for about 4 hours before the reaction was burst with saturated ammonium chloride solution. The reaction solution was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give the crude tetrahydro-2H-thiopyran-4-amine in a yield of 8 g (100%).

References

[1] Patent: WO2008/111009, 2008, A1. Location in patent: Page/Page column 52
[2] Patent: WO2008/111010, 2008, A1. Location in patent: Page/Page column 75
[3] Patent: US2003/232847, 2003, A1. Location in patent: Page 16
[4] Journal of Organic Chemistry, 1981, vol. 46, p. 4376 - 4383
[5] Patent: WO2013/7765, 2013, A1. Location in patent: Page/Page column 110-111

Tetrahydro-2H-thiopyran-4-amine(21926-00-1)Related Product Information

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