4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties

Melting point:

36-41°C

Boiling point:

319.4±32.0 °C(Predicted)

Density 

1.056±0.06 g/cm3(Predicted)

Flash point:

>198℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

10.11±0.10(Predicted)

form 

low melting solid

color 

Light yellow to yellow

InChI

InChI=1S/C11H23N3O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9,12H2,1-3H3

InChIKey

QSYTWBKZNNEKPN-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCN(CCN)CC1

CAS DataBase Reference

192130-34-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933599590

4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Usage And Synthesis

Uses

tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a useful research chemical for the synthesis of biologically active compounds.

Synthesis

GENERAL METHOD: N-substituted phthalimide (2.00 mmol) was mixed with 80% aqueous hydrazine hydrate (2 mL) in ethanol (20 mL) and the reaction was stirred at 70°C for 20 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove the precipitate. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product, which can be used directly in subsequent reactions without further purification.

References

[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 7, p. 2251 - 2259
[2] ChemMedChem, 2014, vol. 9, # 4, p. 752 - 761

4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(192130-34-0)Related Product Information

• 4-(2-AMINO-ETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 1-BOC-4-HYDRAZINOCARBONYLMETHYL PIPERAZINE
• 1-(2-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]ETHYL)-4-PIPERIDINECARBOXYLIC ACID
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• 1-BOC-4-(PYRROLIDIN-3-YL)-PIPERAZINE
• TERT-BUTYL 4-(2-[4-(HYDRAZINOCARBONYL)PIPERIDINO]ETHYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
• T-BUTYL4-[2-AMINO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]PIPERAZINE CARBOXYLATE
• (S)-4-[2-CARBOXY-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ETHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 1-BOC-4-HYDROXYCARBAMIMIDOYLMETHYL PIPERAZINE
• BUTTPARK 90\08-43
• BUTTPARK 77\08-20
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• 4-(1-BENZYLPYRROLIDIN-3-YL)-1-BOC-PIPERAZINE
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• BUTTPARK 77\08-44
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• TERT-BUTYL 4-(2-[2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOL-1-YL]ACETYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE