CELECOXIB-D7 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: 76 mg/ml,Ethanol: 33 mg/ml

form 

A solid

color 

Off-white to gray

CELECOXIB-D7 Usage And Synthesis

Description

Celecoxib-d₇ is intended for use as an internal standard for the quantification of celecoxib by GC- or LC-MS. Celecoxib is a selective inhibitor of COX-2 (IC₅₀s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). It displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition. Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-sterodial anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.

Uses

Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.

CELECOXIB-D7(544686-21-7)Related Product Information

• Celecoxib 2-Methyl Analog
• 4-DesMethyl-3-Methyl Celecoxib
• N-De(4-sulfonaMidophenyl)-N'-(4-sulfonaMidophenyl) Celecoxib
• Celecoxib