EBI-2511
EBI-2511 Basic information
- Product Name:
- EBI-2511
- Synonyms:
-
- EBI-2511
- N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-(1-propan-2-ylpiperidin-4-yl)-1-benzofuran-4-carboxamide
- EBI-2511;EBI2511;EBI 2511;
- 4-Benzofurancarboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-ethyl-6-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-[1-(1-methylethyl)-4-piperidinyl]-
- Histone Methyltransferase,Inhibitor,EBI-2511,inhibit,EBI 2511,EBI2511
- N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-ethyl-6-[ethyl(oxan-4-yl)amino]-2-[1-(propan-2-yl)piperidin-4-yl]-1-benzofuran-4-carboxamide
- CAS:
- 2098546-05-3
- MF:
- C34H48N4O4
- MW:
- 576.77
- Mol File:
- 2098546-05-3.mol
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EBI-2511 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 5 mg/mL (8.67 mM)
- form
- Solid
- color
- White to off-white
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EBI-2511 Usage And Synthesis
Uses
EBI-2511 is a highly potent and orally active EZH2 inhibitor, with an IC50 of 6 nM in Pfeffiera cell lines, respectively.
in vivo
EBI-2511 displays a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. At the same dosage level, EBI-2511 shows a superior anti-tumor efficacy to EPZ-6438 (P<0.01). It is noteworthy that no significant changes in body weights of all treatment groups are observed[1].
IC 50
EZH2
References
[1] Lu B, et al. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. DOI:10.1021/acsmedchemlett.7b00437
EBI-2511Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696,15000506266 15000506266
BOC Sciences
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- 16314854226
- info@bocsci.com
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com