(R)-2-((5-(1H-indazol-5-yl)pyridin-3-yl)amino)-2-phenylethan-1-ol Benzeneethanol, beta-[[5-(1H-indazol-5-yl)-3-pyridinyl]amino]-, (betaR)- Chemical Properties

Boiling point:

631.2±55.0 °C(Predicted)

Density 

1.329±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

13.20±0.40(Predicted)

color 

White to light yellow

(R)-2-((5-(1H-indazol-5-yl)pyridin-3-yl)amino)-2-phenylethan-1-ol Benzeneethanol, beta-[[5-(1H-indazol-5-yl)-3-pyridinyl]amino]-, (betaR)- Usage And Synthesis

Description

VFN38826, also known as CDK8-IN-4, is a CDK8 inhibitor. VFN38826 was first reported in patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM. This product has no formal name at the moment.

Uses

CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.

References

[1] Cheng Z, et al. Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer. WO2014090692A1