7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Basic information
- Product Name:
- 7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
- Synonyms:
-
- 7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE
- TOSLAB 870931
- 1H-Purine-2,6-dione, 7-[(4-chlorophenyl)methyl]-3,7-dihydro-8-[[2-(1H-indol-3-yl)ethyl]amino]-1,3-dimethyl-
- PSB-KK1415
- CAS:
- 885896-26-4
- MF:
- C24H23ClN6O2
- MW:
- 462.93
- Mol File:
- Mol File
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7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Chemical Properties
- Boiling point:
- 729.2±70.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 17.17±0.30(Predicted)
- color
- White to off-white
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7-(4-CHLOROBENZYL)-8-{[2-(1H-INDOL-3-YL)ETHYL]AMINO}-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE Usage And Synthesis
Uses
PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC50 of 19.1 nM[1].
References
[1] Mahardhika AB, et al., Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 27;67(12):9896-9926. DOI:10.1021/acs.jmedchem.3c02423