(11,12-DiHETE Chemical Properties

Boiling point:

515.8±50.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml

pka

4.75±0.10(Predicted)

(11,12-DiHETE Usage And Synthesis

Description

(±)11(12)-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11(12)-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.¹

Definition

ChEBI: 11,12-DiHETE is a polyunsaturated fatty acid and a hydroxy fatty acid.

References

1. Schuchardt, J.P., Schneider, I., Willenberg, I., et al. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA Prostaglandins Other Lipid Mediat. 109-111,23-31(2014).