Penicolinate A Chemical Properties

Boiling point:

557.2±50.0 °C(Predicted)

Density 

1.093±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble

form 

A solid

pka

2.33±0.10(Predicted)

Penicolinate A Usage And Synthesis

Description

Penicolinate A is a fungal metabolite produced by Penicillium sp. BCC16054 with diverse biological activities.¹ It exhibits antimalarial and antituberculosis activity (MICs = 3.25 and 12.5 mg/ml for P. falciparum and M. tuberculosis H37Ra, respectively). Penicolinate A is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC₅₀s = 7.49, 18.43, 4.4, and 14.08 μM, respectively).

References

1. Intaraudom, C., Boonyuen, N., Suvannakad, R., et al. Penicolinates A–E from endophytic Penicillium sp. BCC16054 Tetrahedron Lett. 54(8),744-748(2013).