PF-06860932 Chemical Properties

Boiling point:

697.4±55.0 °C(Predicted)

Density 

1.60±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

3.23±0.30(Predicted)

form 

Solid

color 

White to off-white

PF-06860932 Usage And Synthesis

Biological Activity

CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1]. CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1].

References

[1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1