2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine
2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine Basic information
- Product Name:
- 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine
- Synonyms:
-
- 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine
- 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-4-oxo-2-thioxo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-, methyl ester
- 2’,3’,5’-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine
- CAS:
- 1613530-52-1
- MF:
- C18H22N2O10S
- MW:
- 458.43968
- Mol File:
- 1613530-52-1.mol
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2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine Chemical Properties
- Density
- 1.44±0.1 g/cm3(Predicted)
- pka
- 6.57±0.23(Predicted)
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2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine Usage And Synthesis
Uses
2’,3’,5’-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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