N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine Chemical Properties

Density 

1.29±0.1 g/cm3(Predicted)

pka

9.45±0.43(Predicted)

InChIKey

SWIWEMMZHYDBHD-XZWHSSHBSA-N

SMILES

C(NC1=NC(OCCC#N)=C2C(=N1)N([C@@H]1O[C@H](CO)CN(C(C3=CC=CC=C3)(C3=CC=CC=C3)C3=CC=CC=C3)C1)C=N2)(=O)C(C)C

N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine Usage And Synthesis

Description

N2-Isobutyryl-O6-cyanoethyl-7'-OH-N-trityl-morpholino guanine is a nucleoside, ribonucleoside, and anti-cancer drug. It is modified with two acyl groups at the 2′ position of the sugar moiety and contains a phosphoramidite group in the 5′ position. It is an activator of DNA synthesis in vitro. In vivo studies have shown that N2-Isobutyryl O6 cyanoethyl 7' OH N trityl morpholino guanine can be used as an anticancer agent against human breast cancer cells.