DC1-SMe Chemical Properties

Boiling point:

961.4±65.0 °C(Predicted)

Density 

1.522±0.06 g/cm3(Predicted)

pka

9.47±0.40(Predicted)

form 

Solid

color 

Light yellow to yellow

DC1-SMe Usage And Synthesis

Uses

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC 50

Duocarmycins

References

[1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m