Basic information Safety Supplier Related

S55746 (BCL-201)

Basic information Safety Supplier Related

S55746 (BCL-201) Basic information

Product Name:
S55746 (BCL-201)
Synonyms:
  • S55746 (BCL-201)
  • S55746 hydrochloride
  • S55746 hydrochloride (Synonyms: BLC201 (hydrochloride))
  • S55746 hydrochloride (BLC201 (hydrochloride))
  • BLC201 (hydrochloride)
  • S55746 hydrochloride,S-55746 hydrochloride
CAS:
1448525-91-4
MF:
C43H43ClN4O6
MW:
747.29
Mol File:
1448525-91-4.mol
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S55746 (BCL-201) Chemical Properties

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to yellow
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S55746 (BCL-201) Usage And Synthesis

Description

S55746 hydrochloride is a potent, orally active and selective BCL-2 inhibitor with antitumor activity with low toxicity.

Uses

S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity[1].

in vivo

S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor[1].
S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4;11 and Toledo models time- and dose-dependently[1].

Animal Model:Female SCID/beige mice implanted subcutaneously with 3×106 Toledo or RS4;11[1].
Dosage:20, 50, 100 mg/kg.
Administration:Oral gavage daily for 7 consecutive days.
Result:Induced significant anti-tumor activity time- and dose-dependently.
Animal Model:SCID/beige female mice with RS4;11 tumor xenografts[1].
Dosage:25 and 100 mg/kg.
Administration:Single oral gavage treatment.
Result:Did not induce platelet loss in vivo at 25 and 100 mg/kg.

IC 50

Bcl-2: 1.3 nM (Ki); Bcl-xL: 520 nM (Ki); Bcl-2: 3.9 nM (Kd); Bcl-xL: 186 nM (Kd)

References

[1] Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018 Apr 13;9(28):20075-20088. DOI:10.18632/oncotarget.24744

S55746 (BCL-201)Supplier

Shanghai YuanQi Biotechnology Co., Ltd.
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