5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide Basic information
- Product Name:
- 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
- Synonyms:
-
- 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide
- 184748
- C-FMS-IN-1
- c-Fms inhibitor 1
- 2-Furancarboxamide, 5-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(1-piperidinyl)phenyl]-
- cFmsIN1,c Fms IN 1
- CAS:
- 885703-64-0
- MF:
- C22H27N5O2
- MW:
- 393.48
- Mol File:
- 885703-64-0.mol
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5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide Chemical Properties
- Boiling point:
- 537.6±50.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 5 mg/mL (12.71 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 10.49±0.70(Predicted)
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5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide Usage And Synthesis
Description
c-Fms-IN-1 is a FMS kinase inhibitor with an IC50 of 0.0008 μM[1]. FMS kinase[1]
References
[1]. Illig CR, et al. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8.
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