3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Basic information
- Product Name:
- 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- Synonyms:
-
- 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- 5-CARBOXAMINODOTRYPTAMINE
- 5-CT
- 5-CARBOXAMIDOTRYPTAMINE HEMIETHANOLATE MALEATE SALT
- 5-carboxamidotryptamine
- 2-Carboxyamidotryptamine
- 3-(2-Aminoethyl)-1H-indole-5-carboxamide
- 5-Carboxyamidotryptamine
- CAS:
- 74885-09-9
- MF:
- C11H13N3O
- MW:
- 203.24
- Product Categories:
-
- pharmacetical
- Serotonin receptor
- Mol File:
- 74885-09-9.mol
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Chemical Properties
- Boiling point:
- 513.6±35.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: 10 mg/mL
- form
- solid
- pka
- 16.32±0.30(Predicted)
- color
- white or off-white
- Stability:
- Hygroscopic
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Usage And Synthesis
Uses
5-Carboxamidotryptamine maleate is an agonist of the 5-HT1 receptors.
Definition
ChEBI: 5-carboxamidotryptamine is a member of tryptamines.
in vivo
5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5].
| Animal Model: | Male Swiss Webster mice (20-25 g)[3] |
| Dosage: | 0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.) |
| Administration: | i.p. and i.c.v. |
| Result: | Caused dose-dependent reduction in rectal temperature. |
| Animal Model: | 5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3] |
| Dosage: | 0.1-1 mg/kg |
| Administration: | i.p. and i.c.v. |
| Result: | Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice. |
IC 50
5-HT1A Receptor; 5-HT1B Receptor; 5-HT1D Receptor; 5-HT5A Receptor; 5-HT7 Receptor
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3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE(74885-09-9)Related Product Information
- Indole-5-carboxylic acid
- 5-CARBOXAMIDO[3H]TRYPTAMINE, TRIFLUOROACETATE
- 5-carboxamidotryptamine maleate salt
- 5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]-
- 6-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-6,7,8,9-TETRAHYDRO-5H-CARBAZOLE-3-CARBOXYLIC ACID AMIDE
- 6-AMINO-6,7,8,9-TETRAHYDRO-5H-CARBAZOLE-3-CARBOXYLIC ACID AMIDE
- 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- FROVATRIPTAN
- N,N-DIPROPYL-5-CARBOXAMIDOTRYPTAMINE MALEATE