4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE
4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE Basic information
- Product Name:
- 4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE
- Synonyms:
-
- 4-[1-HYDROXY-2-[(1-METHYLETHYL)AMINO]BUTYL]-1,2-BENZENEDIOL MESYLATE SALT
- 4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE
- ISOETHARINE MESYLATE
- ISOETHARINE MESYLATE SALT
- isoetarine mesilate
- SOYAGMVKMXZVNZ-UHFFFAOYSA-N
- 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol,methanesulfonic acid
- Adrenergic Receptor,Beta Receptor,Inhibitor,Isoetarine,catechol-like,β-adrenergic Receptors Agonist,emphysema,Isoetharine mesylate salt,inhibit,COMT,bronchodilator,bronchitis,Isoetharine
- CAS:
- 7279-75-6
- MF:
- C14H25NO6S
- MW:
- 335.42
- EINECS:
- 230-695-8
- Product Categories:
-
- SYPRINE
- Mol File:
- 7279-75-6.mol
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4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE Chemical Properties
- storage temp.
- 2-8°C
- form
- Solid
- color
- White to off-white
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MSDS
- Language:English Provider:SigmaAldrich
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4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE Usage And Synthesis
Uses
Isoetharine Mesylate Salt is a β-adrenergic receptor agonist. Also, it is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.
Uses
chelating agent
brand name
Bronk ometer (Sanofi Aventis).
Biological Activity
Isoetharine is an agonist for β-adrenergic receptors and is a bronchodilator. It is a catecholic drug metabolized by sulfotransferases and is present in human urine and plasma as a sulfated metabolite. Catechol O-methyltransferase (COMT) also mediates the methylation of isoetharine in the metabolic conjugation pathway.
in vivo
Isoetharine mesylate inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2].
IC 50
β adrenergic receptor
4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATESupplier
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