Basic information Safety Supplier Related

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE

Basic information Safety Supplier Related

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Basic information

Product Name:
3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE
Synonyms:
  • METHYL-3,4-DEPHOSTATIN
  • 3,4-DEPHOSTATIN
  • 3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE
MF:
C7H8N2O3
MW:
168.15
Mol File:
Mol File
More
Less

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Chemical Properties

storage temp. 
2-8°C
solubility 
DMSO: 18 mg/mL, soluble
form 
powder
color 
red-brown
More
Less

Safety Information

WGK Germany 
3

MSDS

More
Less

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Usage And Synthesis

Uses

Methyl-3,4-dephostatin has been used as:

  • an inhibitor for methyltransferases
  • a kinase-related inhibitor for human transglutaminase
  • a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Biochem/physiol Actions

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINESupplier

Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
More
Less

3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE()Related Product Information