3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE
3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Basic information
- Product Name:
- 3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE
- Synonyms:
-
- METHYL-3,4-DEPHOSTATIN
- 3,4-DEPHOSTATIN
- 3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE
- MF:
- C7H8N2O3
- MW:
- 168.15
- Mol File:
- Mol File
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3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: 18 mg/mL, soluble
- form
- powder
- color
- red-brown
MSDS
- Language:English Provider:SigmaAldrich
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3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE Usage And Synthesis
Uses
Methyl-3,4-dephostatin has been used as:
- an inhibitor for methyltransferases
- a kinase-related inhibitor for human transglutaminase
- a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
Biochem/physiol Actions
Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).