6-METHOXYPURINE RIBOSIDE Chemical Properties

Melting point:

140 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))

Boiling point:

610.7±65.0 °C(Predicted)

Density 

1.84±0.1 g/cm3(Predicted)

pka

13.08±0.70(Predicted)

6-METHOXYPURINE RIBOSIDE Usage And Synthesis

Uses

6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Definition

ChEBI: 6-O-methylinosine is inosine carrying a methyl substituent on the oxygen at position 6 on the hypoxanthine ring. It has a role as a metabolite. It is functionally related to an inosine.

References

[1] Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. DOI:10.1096/fj.00-0299com
[2] Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. DOI:10.1203/00006450-198802000-00001

6-METHOXYPURINE RIBOSIDE(5746-29-2)Related Product Information

• 6-Methoxypurine
• O6-CHLOROPHENYL-I CEP
• 6-O-Methyl Guanosine
• O6-METHYLGUANOSINE-5'-TRIPHOSPHATE LITHIUM SALT
• 2-FLUORO-I CEP
• 6-METHOXYPURINE RIBOSIDE