5-ANDROSTENE-3B,16A,17B-TRIOL
5-ANDROSTENE-3B,16A,17B-TRIOL Basic information
- Product Name:
- 5-ANDROSTENE-3B,16A,17B-TRIOL
- Synonyms:
-
- (8R,9S,10R,13S,14S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16,17-triol
- 5-Androstenetriol
- 5-Androstene-3,16,17-triol
- 5-Androstene-3B,16ALPHA,17B-triol
- 5-androstene-3beta,16alpha,17beta-trihydroxy-5-androstene
- 3β,16α,17β-Trihydroxy-5-androstene
- Androst-5-ene-3β,16α,17β-triol
- 5-ANDROSTENE-3B,16A,17B-TRIOL
- CAS:
- 4150-30-5
- MF:
- C19H30O3
- MW:
- 306.4397
- Mol File:
- 4150-30-5.mol
5-ANDROSTENE-3B,16A,17B-TRIOL Chemical Properties
- Melting point:
- 261-264 °C
- Boiling point:
- 449.8±45.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- solubility
- DMSO: soluble; Ethanol: soluble
- form
- A solid
- pka
- 14.52±0.70(Predicted)
5-ANDROSTENE-3B,16A,17B-TRIOL Usage And Synthesis
Uses
5-Androstenetriol is a systemic radiation protector that can boost the host's immunity, leading to increased resistance to infections. 5-Androstenetriol can raise levels of IL-2, IL-3, and IFN, while countering the immunosuppressive effects of Hydrocortisone (HY-N0583)[1][2].
Definition
ChEBI: 5-Androstenetriol is a 3-hydroxy steroid. It has a role as an androgen.
IC 50
IL-2; IL-3
References
[1] R M Loria, et al. Androstenetriol and androstenediol. Protection against lethal radiation and restoration of immunity after radiation injury. Ann N Y Acad Sci. 2000:917:860-7. DOI:10.1111/j.1749-6632.2000.tb05452.x
[2] Mark H Whitnall, et al. Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice. Immunopharmacol Immunotoxicol. 2005;27(1):15-32. DOI:10.1081/iph-51289
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