NADH (sodium salt hydrate)
NADH (sodium salt hydrate) Basic information
- Product Name:
- NADH (sodium salt hydrate)
- Synonyms:
-
- Dihydronicotinamide Adenine Dinucleotide Disodium Salt Hydrate
- adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 1,4-dihydro-1-β-D-ribofuranosyl-3-pyridinecarboxamide, disodium salt, hydrate
- NADH (sodium salt hydrate)
- [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
- -Nicotinamide adenine dinucleotide reduced disodium salt hydrate
- E-TOXATE? KIT
- NADH disodium hydrate
- CAS:
- 1949720-50-6
- MF:
- C21H32N7NaO15P2
- MW:
- 707.46
- Mol File:
- 1949720-50-6.mol
NADH (sodium salt hydrate) Chemical Properties
- storage temp.
- 2-8°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- InChIKey
- ICWJKBZZWRQAHY-NQLDJOIXNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H](N3C=CCC(C(=O)N)=C3)O2)O)O[C@H]1N1C=NC2=C(N=CN=C12)N)O.[NaH].O |&1:1,2,3,15,16,17,19,32,r|
NADH (sodium salt hydrate) Usage And Synthesis
Description
NADH is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH becomes oxidized to produce NAD+. A variety of enzymes use NADH plus H+ to reduce substrates, generating NAD+ as well as the reduced product.
Uses
NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle[1].
in vivo
NADH (5 μmol/mouse; i.p.; once) increases urinary excretion of nicotinamide and its metabolites in mice[2].
NADH (500 mg/kg; i.g.; once) promotes alcohol metabolism and prevents or ameliorates early liver injury caused by acute alcohol exposure in ethanol-loaded mice[3].
NADH (1000 mg/kg; i.p.; once) enhances tissue NAD+ levels in male C57BL/6J mice[3].
| Animal Model: | Male ICR mice[2] |
| Dosage: | 5 μmol/mouse |
| Administration: | Intraperitoneal injection or oral administration, once |
| Result: | Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites. |
| Animal Model: | Male C57BL/6J mice[3] |
| Dosage: | 500 mg/kg |
| Administration: | Intragastric administration, 15 min before ethanol administration |
| Result: | Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes. |
References
[1] Ying W. NAD+ and NADH in cellular functions and cell death. Front Biosci. 2006 Sep 1;11:3129-48. DOI:10.2741/2038
[2] Kimura N, et al. Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH. J Nutr Sci Vitaminol (Tokyo). 2006 Apr;52(2):142-8. DOI:10.3177/jnsv.52.142
[3] Wu K, et al. NADH and NRH as potential dietary supplements or pharmacological agents for early liver injury caused by acute alcohol exposure. Journal of Functional Foods, 2021, 87: 104852.
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