MK-886
MK-886 Basic information
- Product Name:
- MK-886
- Synonyms:
-
- 3-[TERT-BUTYLTHIO-1-(4-CHLOROBENZYL)-5-ISOPROPYL-1H-INDOL-2-YL]-2,2-DIMETHYLPROPIONIC ACID, SODIUM SALT
- 1-[(4-CHLOROPHENYL)METHYL]-3-[(1,1-DIMETHYLETHYL)THIO]-ALPHA,ALPHA-DIMETHYL-5-(1-METHYLETHYL)-1H-INDOLE-2-PROPANOIC ACID, SODIUM SALT
- 3-[3-TERT-BUTYLTHIO-1-(4-CHLOROBENZYL)-5-ISOPROPYL-1H-INDOL-2-YL]-2,2-DIMETHYLPROPIONIC ACID, SODIUM
- 3-[1-(P-CHLOROBENZYL)-5-(ISOPROPYL)-3-T-BUTYLTHIOINDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID, NA
- 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid,sodium
- 3-[3-tert-butylthio-1-(4-chlorobenzyl)-5-isopropyl-1h-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt hydrate
- mk-886 sodium hydrate
- 3-[3-tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, hydrate sodium salt
- CAS:
- 118427-55-7
- MF:
- C27H33ClNNaO2S
- MW:
- 494.06
- Mol File:
- 118427-55-7.mol
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MK-886 Chemical Properties
- Melting point:
- 275-278°C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
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MK-886 Usage And Synthesis
Chemical Properties
White Solid
Uses
MK-886 is a leukotriene inhibitor. MK-886 and Celecoxib have an inhibitory effect on the growth of pancreatic cancer cell line SW1990 and angiogenesis.
in vivo
MK-886 sodium salt (L 663536; 5 mg/kg; oral administration; male Sprague-Dawley rats) treatment potently inhibits the antigen-induced dyspnea in inbred rats pretreated with methysergide[2].
?
MK-886 sodium salt (L 663536) inhibits leukotriene biosynthesis in vivo in a rat pleurisy model (ED50, 0.2 mg/kg p.o.), an inflamed rat paw model (ED50, 0.8 mg/kg), a model of leukotriene excretion in rat bile following antigen provocation[2].
MK-886Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- 021-50182298 021-50180596
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Chemsky（shanghai）International Co.,Ltd.
- Tel
- 021-50135380
- shchemsky@sina.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn