4-IODOPHENYL ISOCYANATE Chemical Properties

Melting point:

44-48 °C(lit.)

Boiling point:

84°C 5mm

Density 

1.79±0.1 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

fused solid

color 

White

Sensitive 

Moisture & Light Sensitive

BRN 

2716151

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-26-36

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

II

HS Code 

2929100090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-IODOPHENYL ISOCYANATE Usage And Synthesis

Uses

4-Iodophenyl isocyanate may be used in the preparation of:

• silicon-stereogenic silicon-bridged arylpyridinones
• N-(4-iodophenyl)cholesteryl-3-carbamate
• N-(4-iodophenyl)pregnenolone-3-carbamate

Preparation

To a solution of triphosgene (3.0 g, 10 mmol) and triethylamine (2.02 g, 20 mmol) in dry benzene (30 mL), a solution of 4-iodoaniline (4.3 g, 20 mmol) in dry benzene (15 mL) was added over 20 min. During the course of the addition, the temperature of the reaction mixture was increased from ambient to reflux temperature. After refluxing for 3 h, the reaction mixture was filtered. The filtrate was concentrated to obtain a residue, which was subjected to distillation under reduced pressure to afford a colorless liquid. Yield 2.21 g (45.2%).

4-IODOPHENYL ISOCYANATE(15845-62-2)Related Product Information

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