Basic information Safety Supplier Related

2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE

Basic information Safety Supplier Related

2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE Basic information

Product Name:
2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE
Synonyms:
  • 3'-O-(2-Methoxyethyl)-2-aminoadenosine
  • Adenosine, 2-amino-3'-O-(2-methoxyethyl)-
  • 3'-MOE-2-amino-Adenosine
  • 2-Amino-3'-O-(2-methoxyethyl)adenosine
  • 2-Amino-3'-O-(2-methoxyethyl)adenosine
  • (2R,3R,4S,5R)-2-(2,6-diamino-9H-purin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol
CAS:
256224-02-9
MF:
C13H20N6O5
MW:
340.34
Mol File:
256224-02-9.mol
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2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE Chemical Properties

Boiling point:
734.5±70.0 °C(Predicted)
Density 
1.81±0.1 g/cm3(Predicted)
pka
12.95±0.70(Predicted)
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2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE Usage And Synthesis

Uses

3’-O-(2-Methoxyethyl)-2-aminoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020

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