2,6-DICHLORO-5-FLUORONICOTINAMIDE Chemical Properties

Melting point:

160-162

Boiling point:

259.0±40.0 °C(Predicted)

Density 

1.614±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

crystalline solid

pka

13.36±0.50(Predicted)

color 

White

InChI

InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12)

InChIKey

ZVYNUGSPFZCYEV-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=C(F)C=C1C(N)=O

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933399990

2,6-DICHLORO-5-FLUORONICOTINAMIDE Usage And Synthesis

Uses

2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer.

2,6-DICHLORO-5-FLUORONICOTINAMIDE(113237-20-0)Related Product Information

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