1D-MYO-INOSITOL-1,3,4,5-TETRAKISPHOSPHATE, (NA+ SALT) Chemical Properties

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Lyophilized Powder

color 

White to off-white

1D-MYO-INOSITOL-1,3,4,5-TETRAKISPHOSPHATE, (NA+ SALT) Usage And Synthesis

Description

D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P₄) is formed by the phosphorylation of Ins(1,4,5)P₃ by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P₄ increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.

Uses

D-myo-Inositol-1,3,4,5-tetraphosphate sodium is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase.

References

[1] D. BILLINGTON. Synthesis of myo-inositol 1-phosphate and 4-phosphate, and of their individual enantiomers[J]. Journal of The Chemical Society, Chemical Communications, 1987, 6 10-11: 314-316. DOI: 10.1039/c39870000314
[2] D COMMUNI  C E  V Vanweyenberg. Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets.[J]. Biochemical Journal, 1994, 298 Pt 3: 669-673. DOI: 10.1042/bj2980669
[3] ANDREAS LüCKHOFF  David E C. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel[J]. Nature, 1992, 355 6358: 356-358. DOI: 10.1038/355356a0

1D-MYO-INOSITOL-1,3,4,5-TETRAKISPHOSPHATE, (NA+ SALT)(210488-61-2)Related Product Information

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