MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT) Chemical Properties

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

≥15.97 mg/mL in EtOH with gentle warming and ultrasonic; ≥50.7 mg/mL in H2O; ≥77.8 mg/mL in DMSO

form 

solid

pka

3.39±0.20(Predicted)

Water Solubility 

Soluble to 2 mg/ml in water

Sequence

Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro

MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT) Usage And Synthesis

Uses

Myelin Basic Protein(87-99) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS)[1][2].

storage

Store at -20°C

References

[1] R E Jones, et al. The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats. J Neuroimmunol. 1992 Apr;37(3):203-12. DOI:10.1016/0165-5728(92)90004-5
[2] George Deraos, et al. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease. J Med Chem. 2008 Dec 25;51(24):7834-42. DOI:10.1021/jm800891n

MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT)(118506-26-6)Related Product Information

• H-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-PRO-OH
• H-THR-PRO-OH
• H-SER-PRO-OH
• MYELIN BASIC PROTEIN (87-99) (HUMAN, BOVINE, RAT)