ITE
ITE Basic information
- Product Name:
- ITE
- Synonyms:
-
- ITE
- 2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER
- 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID
- 2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester
- Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
- methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
- ARYL HYDROCARBON RECEPTOR LIGAND
- 4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
- CAS:
- 448906-42-1
- MF:
- C14H10N2O3S
- MW:
- 286.31
- Mol File:
- 448906-42-1.mol
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ITE Chemical Properties
- Melting point:
- 234 - 236°C
- Boiling point:
- 520.4±48.0 °C(Predicted)
- Density
- 1.427±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 30 mg/mL, soluble
- form
- solid
- pka
- 14.38±0.30(Predicted)
- color
- Off-White to Light Yellow
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MSDS
- Language:English Provider:SigmaAldrich
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ITE Usage And Synthesis
Uses
ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.
Definition
ChEBI: 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester is an indolyl carboxylic acid.
Biological Activity
Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β -naphthoflavone. Active in vivo .
storage
Store at RT
ITESupplier
Shanghai Luofa Biochemical Technology Co., Ltd. Gold
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- 021-51111890 15317326293
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3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Nanjing Norris-Pharm Technology Co., Ltd
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- 13901585132
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Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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Mashilabs (Shanghai) Co.,Ltd.
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- 19916721580
- mafarm@126.com