1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE CAS#: 13877-76-4

1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE Basic information

Product Name:

1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

Synonyms:

3-(beta-d-ribofuranosyl)pyrazolo(4,3-d)6(h)-7-ketopyrimidine
3-d)pyrimidin-7-one,1,4-dihydro-3-beta-d-ribofuranosyl-7h-pyrazolo(
3-d)pyrimidin-7-one,1,6-dihydro-3-beta-d-ribofuranosyl-7h-pyrazolo(
OHYAMYCIN
FORMYCIN B
LAURUSIN
7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-.beta.-D-ribofuranosyl-
(1S)-1,4-Anhydro-1-C-[1,4-dihydro-7-oxo-7H-pyrazolo[4,3-d]pyrimidin-3-yl]-D-ribitol

CAS:

13877-76-4

MF:

C10H12N4O5

MW:

268.23

Mol File:

13877-76-4.mol

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1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE Chemical Properties

Melting point:: 254-255 °C (decomp)
Boiling point:: 777.5±60.0 °C(Predicted)
Density: 2.18±0.1 g/cm3(Predicted)
pka: 10.92±0.20(Predicted)

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Safety Information

Toxicity: LD50 intravenous in mouse: 1gm/kg

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1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE Usage And Synthesis

Uses

Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia[1][2].

Definition

ChEBI: Formycin B is a formycin.

References

[1] Rainey P, et al., Metabolism and mechanism of action of formycin B in Leishmania. Proc Natl Acad Sci U S A. 1983 Jan;80(1):288-92. DOI:10.1073/pnas.80.1.288
[2] Ishizuka M, et al., Biological studies on formycin and formycin B. J Antibiot (Tokyo). 1968 Jan;21(1):5-12. DOI:10.7164/antibiotics.21.5

1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONESupplier

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