3-Bromo-5-ethoxy-4-hydroxybenzaldehyde Chemical Properties

Melting point:

141-143°C

Boiling point:

303.8±37.0 °C(Predicted)

Density 

1.568±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

6.39±0.23(Predicted)

Appearance

White to off-white Solid

Sensitive 

Air Sensitive

CAS DataBase Reference

3111-37-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2913000090

MSDS

• Language:English Provider:ALFA

3-Bromo-5-ethoxy-4-hydroxybenzaldehyde Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-bromo-5-ethoxy-4-hydroxybenzaldehyde from the compound (CAS: 1567388-59-3): a mixture of substrate 1a (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 equivalents) in ethylene glycol (EG, 5 mL) was stirred and reacted for 8 hr at 80 °C under oxygen (1 atm) atmosphere. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were sequentially added to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL x 2). All organic phases were combined, dried with anhydrous sodium sulfate and concentrated to obtain the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10:1) to afford the target product 3-bromo-5-ethoxy-4-hydroxybenzaldehyde (2a).

References

[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411

3-Bromo-5-ethoxy-4-hydroxybenzaldehyde(3111-37-3)Related Product Information

• 4-Hydroxybenzaldehyde
• Ethoxyquin
• 3-BROMO-4-HYDROXYBENZALDEHYDE
• Salicylaldehyde
• Benzaldehyde
• 4-Dimethylaminobenzaldehyde
• Bromine
• 3-BROMO-4-[(2-CHLOROBENZYL)OXY]-5-ETHOXYBENZALDEHYDE
• 4-(BENZYLOXY)-3-BROMO-5-ETHOXYBENZALDEHYDE
• Ethoxy
• AKOS B004953
• 3-BROMO-4,5-DIETHOXY-BENZALDEHYDE
• 3-BROMO-5-ETHOXY-4-METHOXYBENZALDEHYDE
• 5-BROMO-3-ETHOXY-2-HYDROXYBENZALDEHYDE
• 3-Bromo-5-ethoxy-4-hydroxybenzaldehyde
• DIHYDROXY BENZALDEHYDE
• AKOS B004935
• SPECS AN-655/15531046