SULFURETIN
SULFURETIN Basic information
- Product Name:
- SULFURETIN
- Synonyms:
-
- SULFURETIN
- 6,3',4'-TRIHYDROXYAURONE
- 3',4',6-TRIHYDROXYAURONE
- 2-(3,4-dihydroxybenzylidene)-6-hydroxy-2H-benzofuran-3-one
- (Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-2H-benzofuran-3-one
- SULPHURETIN
- SULFURETIN WITH HPLC
- SULFURETIN hplc
- CAS:
- 120-05-8
- MF:
- C15H10O5
- MW:
- 270.24
- EINECS:
- 204-366-4
- Product Categories:
-
- Aurones
- Mol File:
- 120-05-8.mol
SULFURETIN Chemical Properties
- Melting point:
- 295°C
- storage temp.
- 2-8°C
- solubility
- Acetone: Soluble
Chloroform: Soluble
Dichloromethane: Soluble
DMSO: SolubleEthyl Acetate: Soluble - form
- Solid
- color
- Yellow to orange
- LogP
- 1.980 (est)
SULFURETIN Usage And Synthesis
Uses
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2].
Definition
ChEBI: Sulfuretin is a member of 1-benzofurans.
Biological Activity
Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory
in vivo
Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1].
| Animal Model: | Pathogen-free male BALB/c mice (7-8 weeks old)[1] |
| Dosage: | 40 μg/kg |
| Administration: | A single intraperitoneal injection was administered 2 h after the last OVA challenge |
| Result: | Suppressed OVA-induced chemotaxis and airway inflammation. |
References
[1] Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. DOI:10.1016/j.bbrc.2010.08.014
[2] Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771.
[3] SO YOUNG KANG Myung J O Ji Young Kang. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.[J]. Journal of Microbiology, 2012, 50 2: 293-300. DOI: 10.1007/s12275-012-2068-7
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