ORYZANOL
ORYZANOL Basic information
- Product Name:
- ORYZANOL
- Synonyms:
-
- Oryzanol C
- ORYZANOL
- 24-Methylene cycloartanyl ferulate
- Oryzanol C (24-Methylene Cycloartanyl Ferulate)
- 9,19-Cyclolanostan-3-ol, 24-methylene-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate, (3β)-
- 469-36-3 ORYZANOL
- Oryzanol Impurity 2(Oryzanol C)
- Oryzanol impurity 12
- CAS:
- 469-36-3
- MF:
- C41H60O4
- MW:
- 616.93
- Product Categories:
-
- Herb extract
- Mol File:
- 469-36-3.mol
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ORYZANOL Chemical Properties
- Melting point:
- 193-194 °C
- Boiling point:
- 668.4±40.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- pka
- 8?+-.0.20(Predicted)
- form
- Solid
- color
- White to off-white
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ORYZANOL Usage And Synthesis
Uses
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC50= 33.3μM)[1].
IC 50
Akt1: 33.3 μM (EC50)
References
[1] Heon Woong Kim, et al. 24-Methylenecycloartanyl ferulate, a major compound of γ-oryzanol, promotes parvin-beta expression through an interaction with peroxisome proliferator-activated receptor-gamma 2 in human breast cancer cells. Biochem Biophys Res Commun. 2015 Dec 25;468(4):574-9. DOI:10.1016/j.bbrc.2015.10.147
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