[2H8]-Bendamustine Hydrochloride
[2H8]-Bendamustine Hydrochloride Basic information
- Product Name:
- [2H8]-Bendamustine Hydrochloride
- Synonyms:
-
- [2H8]-Bendamustine Hydrochloride
- [2H8]-Bendamustine hydrochloride salt
- Bendamustine-d8 HCl
- Bendamustine hydrochloride salt
- CAS:
- 1185068-23-8
- MF:
- C16H22Cl3N3O2
- MW:
- 394.72
- Mol File:
- 1185068-23-8.mol
[2H8]-Bendamustine Hydrochloride Usage And Synthesis
Uses
Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. DOI:10.1158/1078-0432.CCR-07-1061
[3] Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. DOI:10.1016/j.cellsig.2013.01.020
[4] Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. DOI:10.1111/j.1476-5381.2012.02048.x
[2H8]-Bendamustine Hydrochloride(1185068-23-8)Related Product Information
- 5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 1-Methylethyl Ester
- 4-[-((-((4-(5-(Bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoyl)oxy)ethyl)(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanic Acid
- N1-Methylbenzene-1,2,4-triaMine
- Bendamustine Deschloro Dimer Impurity
- 5-[Bis(2-chloroethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Methyl Ester
- 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Ethyl Ester
- Bendamustine Related Impurity 9
- Bendamustine Related Impurity 22
- BendaMustine DiMer 2'-Allyl Ester
- Bendamustine o-mannitol Ester
- Bendamustine-D-Mannose Adduct
- Bendamustine Related Impurity 3
- Bendamustine Related Impurity 12
- Bendamustine Related Impurity 8
- Bendamustine Related Impurity 21
- Bendamustine Related Impurity 19
- Bendamustine Related Impurity 6 (Mixture of Isomers)
- BendaMustine Dideschloroethyl