ChemicalBook > Product Catalog > Organic Chemistry > Alcohols,Phenols,Phenol alcohols > VH 032, phenol
VH 032, phenol
VH 032, phenol Basic information
- Product Name:
- VH 032, phenol
- Synonyms:
-
- VH 032, phenol
- VH032-OH
- (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazol-5-yl)benzyl]pyrrolidine-2-carboxamide, L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-{[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
- L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- CAS:
- 2244684-42-0
- MF:
- C24H32N4O5S
- MW:
- 488.6
- Mol File:
- 2244684-42-0.mol
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VH 032, phenol Chemical Properties
- Boiling point:
- 823.8±65.0 °C(Predicted)
- Density
- 1.296±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.12±0.35(Predicted)
- form
- Solid
- color
- White to light yellow
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VH 032, phenol Usage And Synthesis
Uses
VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
reaction suitability
reagent type: ligand
IC 50
VHL
storage
Store at -20°C
References
[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8(1):830. Published 2017 Oct 10. DOI:10.1038/s41467-017-00954-1
VH 032, phenolSupplier
Daicel Chiral Technologies (China)CO.,LTD
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