Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antiparasitic drugs >  Antifilarial and Leishmaniasis Drugs >  bis(8-hydroxyquinolinium) sulphate

bis(8-hydroxyquinolinium) sulphate

Basic information Safety Supplier Related

bis(8-hydroxyquinolinium) sulphate Basic information

Product Name:
bis(8-hydroxyquinolinium) sulphate
Synonyms:
  • 2-Hydroxy-4,4'-stilbenedicarboxamidine
  • 2-Hydroxystilbene-4,4'-dicarboxamidine
  • Benzenecarboximidamide, 4-[2-[4-(aminoiminomethyl)phenyl]ethenyl]-3-hydroxy-
  • bis(8-hydroxyquinolinium) sulphate USP/EP/BP
CAS:
495-99-8
MF:
C16H16N4O
MW:
280.32
EINECS:
207-811-0
Mol File:
495-99-8.mol
More
Less

bis(8-hydroxyquinolinium) sulphate Chemical Properties

Melting point:
235°
More
Less

Safety Information

Toxicity
LD50 in mice (mg/g); 0.027 i.v.; 0.14 s.c. (Ewins, 1950)
More
Less

bis(8-hydroxyquinolinium) sulphate Usage And Synthesis

Originator

Hydroxystilbamidin,Merrell National,US,1954

Definition

ChEBI: Hydroxystilbamidine is a stilbenoid.

Manufacturing Process

Preparation of 2-Nitro-4,4'-Dicyanostilbene: 10 grams of 2-nitro-ptolunitrileand 8.1 grams of 4-cyano-benzaldehyde were heated to 170° to 180°C, 1.2 and 0.6 cc of piperidine were added at quarter-hour intervals, heating was continued for a further one and a quarter hours, the product cooled, triturated with glacial acetic acid and filtered. The residue was crystallized from glacial acetic acid as yellow needles, MP 290°C.
Preparation of 2-Amino-4,4'-Dicyanostilbene: 10.0 grams of 2-nitro-4,4'- dicyanostilbene thus prepared were suspended in 200 cc of glacial acetic acid and a hot solution of 50 grams of stannous chloride (SnCl2 · 2H2O) in 50 cc of concentrated hydrochloric acid was quickly added. Rapid reaction occurred and the boiling was continued for a further 4 minutes, the reaction mixture was cooled, filtered, and the stannous chloride residue decomposed with 25% aqueous caustic soda solution. The liberated amine crystallized from glacial acetic acid as yellow needles, MP 232°C.
Preparation of 2-Hydroxy-4,4'-Dicyanostilbene: 10 grams of 2-amino-4,4'- dicyanostilbene thus prepared were dissolved in 400 cc of boiling glacial acetic acid and 200 cc of dilute sulfuric acid added; the solution was suddenly chilled and diazotized over one and a half hours at 5° to 10°C with sodium nitrate (3.0 grams/15 cc H2O). The diazonium salt solution was decomposed by boiling for 15 minutes with 600 cc of 55% aqueous sulfuric acid solution; the solution was diluted, cooled and filtered. The residue crystallized from ethyl alcohol as lemon yellow prismatic needles, MP 296°C
Preparation of 2-Hydroxy -4,4'-Diamidinostilbene Dihydrochloride: 10 grams of 2-hydroxy-4,4'-dicyanostilbene were suspended in 250 cc of absolute ethyl alcohol and the mixture saturated with dry hydrogen chloride at 0°C. The whole was left for eight days at room temperature. The imino-ether hydrochloride formed was filtered off, washed with dry ether and dried in the air for a short time. It was then added to 250 cc of 10% ethyl alcoholic ammonia and the whole heated for 5 hours at 45°C. The 2-hydroxy-4,4'- diamidinostilbene dihydrochloride which separated was crystallized from 10% hydrochloric acid. It forms pale yellow needles, MP 357°C (decomposition).
Preparation of the Final Isethionate Product: The diisethionate may be produced by treating a solution of the dihydrochloride with alkali carbonate, separating and dissolving the resultant base in aqueous isethionic acid and precipitating the diisethionate with acetone. The product may be purified by dissolving in hot methyl alcohol containing a trace of water followed by precipitation by the cautious addition of acetone. The diiseihionate has a MP of 286°C.

Therapeutic Function

Fungicide

bis(8-hydroxyquinolinium) sulphateSupplier

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com