propylhexedrine Chemical Properties

Boiling point:

bp760 205°; bp20 92-93°

Density 

d425 0.8501

refractive index 

nD20 1.4600

pka

pKa 10.52(H2O,t =25±0.2,I≤0.001) (Uncertain)

propylhexedrine Usage And Synthesis

Uses

Adrenergic (vasoconstrictor).

Definition

ChEBI: Propylhexedrine is a secondary amino compound.

brand name

Dristan Inhaler (Whitehall-Robins);Benzedrex;Chp-depot;Cyclexedrine;Eggobesin;Eventin.

World Health Organization (WHO)

Propylhexedrine, a sympathomimetic amine, has been widely available since 1949 in over-the-counter inhalants for nasal decongestion and in oral anorexic preparations. As dependence can occur and because abuse has been reported, propylhexedrine was subjected in 1986 to control under Schedule IV of the 1971 Convention on Psychotropic Substances. (Reference: (WHTAC2) 2nd Report of the WHO Expert Committee on Drug Dependence (IV), 729, , 1985)

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5270, 1958 DOI: 10.1021/ja01552a063

General Description

Propylhexedrine is another analog ofamphetamine in which the aromatic ring has been replacedwith a cyclohexane ring. This drug produces vasoconstrictionand a decongestant effect on the nasal membranes, butit has only about one half the pressor effect of amphetamineand produces decidedly fewer effects on the CNS. Its majoruse is for a local vasoconstrictive effect on nasal mucosa inthe symptomatic relief of nasal congestion caused by thecommon cold, allergic rhinitis, or sinusitis.

Synthesis

Propylhexedrine is prepared by catalytic hydrogenation of (±)- or (-)-ephedrine in a strong mineral acid .