chlornaphazine Chemical Properties

Melting point:

54-56°

Boiling point:

bp5 210°

Density 

1.2039 (rough estimate)

refractive index 

1.6300 (estimate)

pka

2.75±0.70(Predicted)

color 

Platelets from pet ether

IARC

1 (Vol. 4, Sup 7, 100A) 2012

EPA Substance Registry System

Chlornaphazine (494-03-1)

Safety Information

Hazardous Substances Data

494-03-1(Hazardous Substances Data)

Toxicity

LD50 intraperitoneal in mouse: 1300mg/kg

chlornaphazine Usage And Synthesis

Description

Chlornaphazine is composed of clear, colorless plates or may be a brown solid. Molecularweight=268.2; Freezing/Melting point=54-56℃.Slightly soluble in water; solubility=, 1 mg/mL at 22℃.

Chemical Properties

Chlornaphazine is composed of clear, colorless plates or may be a brown solid.

Definition

ChEBI: Chlornaphazine is a member of naphthalenes.

brand name

Aleukon;Chloronaftina;Nafticlorina;Naphthylamine mustard.

World Health Organization (WHO)

The World Health Organization has no information further to the above regarding preparations containing chlornaphazine or to indicate that they are still commercially manufactured.

General Description

Colorless plates or brown solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

chlornaphazine reacts with nucleophiles .

Fire Hazard

Flash point data are not available for chlornaphazine , but chlornaphazine is probably combustible.

Safety Profile

Confirmed human carcinogenproducing bladder tumors. Human and experimentalcarcinogenic data. Moderately toxic by intraperitonealroute. When heated to decomposition it emits very toxicfumes of Cl- and NOx.

Potential Exposure

May be combustible and possibly explosive. Not produced or used commercially in the United States, Chlornaphazine has been used in other countries in the treatment of leukemia and related cancers. Currently, this drug does not have wide therapeutic usage.

First aid

Eye Contact: Remove any contact lenses at once.Immediately flush eyes well with copious quantities ofwater or normal saline for at least 20-30 min. Seek medicalattention. Inhalation: Leave contaminated area immediately; breathe fresh air. Proper respiratory protection mustbe supplied to any rescuers. If coughing, difficult breathingor any other symptoms develop, seek medical attention atonce, even if symptoms develop many hours after exposure.Ingestion: Contact a physician, hospital or poison center atonce. If the victim is unconscious or convulsing, do notinduce vomiting or give anything by mouth. Assure that thepatient’s airway is open and lay him on his side with hishead lower than his body and transport immediately to amedical facility. If conscious and not convulsing, give aglass of water to dilute the substance. Vomiting should notbe induced without a physician’s advice.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a refrigerator or a cool, dry place. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHAStandard 1910.1045.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise it from pet ether. At 15o it is soluble in EtOH (3.2%), Et2O (50%), Me2CO (84%) and *C6H6 (80%). [Beilstein 12 III 2996, 12 IV 3126.] CARCINOGENIC.

Incompatibilities

Keep away from oxidizers, nucleophiles, and nitromethanes. Amines may react violently with nitric acid; cellulose nitrate (of high surface area); 1-chloro-2,3-epoxypropane (exothermic reaction may occur). Incompatible with acids, acid halides; alcohols, aldehydes, alkylene oxides; anhydrides, cresols, caprolactam solution; epichlorohydrin, epoxides, isocyanates, glycols, peroxides, phenols. Contact with strong reducing agents may generate flammable hydrogen gas. May attack copper and copper alloys.

Waste Disposal

Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.

chlornaphazine (494-03-1)Related Product Information

• Chlormethine
• 7-(BIS(2-CHLOROETHYL)AMINO)-2-NITRONAPHTHO(2,1-B)FURAN
• chlornaphazine