terofenamate Chemical Properties

Melting point:

73-74°

Density 

1.3318 (rough estimate)

refractive index 

1.6140 (estimate)

Safety Information

Toxicity

LD50 in mice, rats (mg/kg): 918, 307 orally; 300, 274 i.p. (Chieli)

terofenamate Usage And Synthesis

Originator

Etofen Ilfi,Lusofarmaco,Italy,1980

Manufacturing Process

10 g sodium salt of N-2,6-dichloro-m-tolylanthranilic acid, 3 ml chloromethyl ethyl ether and 80 ml dry acetone were refluxed for 12 hours on waterbath under stirring. The solid was filtered off, and the solution evaporated to dryness. The residue was dissolved in chloroform, washed with sodium carbonate solution, then with water until neutral. After drying on sodium sulfate, the solution was evaporated to dryness. The obtained product was recrystallized from 95% ethanol. Melting point 73°C to 74°C.

Therapeutic Function

Antiinflammatory, Analgesic

terofenamate(29098-15-5)Related Product Information

• N-Phenylanthranilic acid
• N-(2-CHLOROPHENYL)ANTHRANILIC ACID
• 2,6-Dichloro-3-methylaniline
• 2-[(2-Chlorophenyl)amino]-benzaldehyde
• 2,6-DICHLORODIPHENYLAMINE
• N-(3-METHYLPHENYL)ANTHRANILIC ACID
• 2-[(2,6-dichlorophenyl)amino]benzoicacid
• Meclofenamic acid
• 2-(2,6-DICHLORO-PHENYLAMINO)-BENZOIC ACID METHYL ESTER
• terofenamate
• (2-CHLORO-PHENYL)-PHENYL-AMINE
• (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL
• 2-(2,6-Dichloroanilino) benzaldehyde
• 2-Anilinobenzoic acid methyl ester